The volume collects the contributions of a seminar entitled “Siena and earthquakes. Multidisciplinary points of view for an archaeoseismological reading of the historic center" held on 10 June 2022 at the Department of Historical Sciences and Cultural Heritage of the University of Siena. The study day and this book are part of the communication and dissemination activities of the PROTECT – Knowledge for PReventiOn project. TEChnique for reparing seismic damage from medieval period To modern era, a two-year research funded by the European Commission with a Horizon 2020 – Marie Sklodowska-Curie Individual Fellowship, currently underway at the École Normale Supérieure in Paris. The book aims to highlight different methodological approaches for the study of the historic center of Siena, with a view to building a first knowledge base on the seismicity that affected the city and on the historical, architectural, geological and territorial characteristics of the context itself. The articles covered different aspects and criteria of documentation and analysis of the earthquakes that occurred in Siena in a chronological span that runs from the XNUMXth to the XNUMXth century, proposing an interconnected narrative between different disciplines linked by a single common thread, that of knowledge in prevention function.